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Nurses can provide education about lifestyle modifications, such as reducing caloric intake, increasing physical activity, and creating sustainable lifelong healthy habits to preventing rebound weight gain after discontinuing pharmacotherapy

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Clinical evidence is limited for transdermal semaglutide

However, the ability of AST to activate the Nrf2-ARE signaling pathway in cellular experiments remains controversial, and if it exists, the activation capacity is relatively weak [68,72,77,78]

It mimics hormones that regulate appetite and blood sugar levels, leading to increased insulin production, reduced cravings, and a natural sense of fullness, helping individuals maintain a lower calorie intake